Hazuda, Daria J.: search on Z-Library

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1

Emerging Pharmacology: Inhibitors of Human Immunodeficiency Virus Integration

Hazuda, Daria, Iwamoto, Marian, Wenning, Larissa

Journal:

Annual Review of Pharmacology

Year:

2009

Language:

english

File:

PDF, 448 KB

english, 2009

2

Mechanistic Study of Common Non-Nucleoside Reverse Transcriptase Inhibitor-Resistant Mutations with K103N and Y181C Substitutions

Lai, Ming-Tain, Munshi, Vandna, Lu, Meiqing, Feng, MeiZhen, Hrin-Solt, Renee, McKenna, Philip, Hazuda, Daria, Miller, Michael

Journal:

Year:

2016

Language:

english

File:

PDF, 2.39 MB

english, 2016

3

Isolation, Structure, Absolute Stereochemistry, and HIV-1 Integrase Inhibitory Activity of Integrasone, a Novel Fungal Polyketide

Herath, Kithsiri B., Jayasuriya, Hiranthi, Bills, Gerald F., Polishook, Jon D., Dombrowski, Anne W., Guan, Ziqiang, Felock, Peter J., Hazuda, Daria J., Singh, Sheo B.

Journal:

Journal of Natural Products

Year:

2004

Language:

english

File:

PDF, 54 KB

english, 2004

4

In Vitro Resistance Selection with Doravirine (MK-1439), a Novel Nonnucleoside Reverse Transcriptase Inhibitor with Distinct Mutation Development Pathways

Feng, Meizhen, Wang, Deping, Grobler, Jay A., Hazuda, Daria J., Miller, Michael D., Lai, Ming-Tain

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2015

Language:

english

File:

PDF, 1.33 MB

english, 2015

5

Isolation, Structure and HIV-1 Integrase Inhibitory Activity of Exophillic Acid, a Novel Fungal Metabolite from Exophiala pisciphila.

John G. Ondeyka, Deborah L. Zink, Anne W. Dombrowski, Jon D. Polishook, Peter J. Felock, Daria J. Hazuda, Sheo B. Singh

Journal:

Year:

2004

File:

PDF, 69 KB

2004

6

Combinatorial synthesis of CCR5 antagonists

Christopher A Willoughby, Scott C Berk, Keith G Rosauer, Silvia Degrado, Kevin T Chapman, Sandra L Gould, Martin S Springer, Lorraine Malkowitz, William A Schleif, Daria Hazuda, Michael Miller, Joseph

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 147 KB

english, 2001

7

Human Interleukin 1β Is Not Secreted from Hamster Fibroblasts When Expressed Constitutively from a Transfected cDNA

Peter R. Young, Daria J. Hazuda and Philip L. Simon

Journal:

The Journal of Cell Biology

Year:

1988

Language:

english

File:

PDF, 920 KB

english, 1988

8

Scintillation proximity assays for mechanistic and pharmacological analyses of HIV-1 integration

Jay A. Grobler, Kara A. Stillmock, Daria J. Hazuda

Journal:

Year:

2009

Language:

english

File:

PDF, 263 KB

english, 2009

9

Expression of latent human immunodeficiency type 1 is induced by novel and selective histone deacetylase inhibitors

Archin, Nancie M, Keedy, Kara S, Espeseth, Amy, Dang, Herbert, Hazuda, Daria J, Margolis, David M

Journal:

Year:

2009

Language:

english

File:

PDF, 1.30 MB

english, 2009

10

Doravirine Suppresses Common NNRTI-associated Mutants at Clinically Relevant Concentrations

Feng, Meizhen, Sachs, Nancy A., Xu, Min, Grobler, Jay, Blair, Wade, Hazuda, Daria J., Miller, Michael D., Lai, Ming-Tain

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2016

Language:

english

File:

PDF, 989 KB

english, 2016

11

Structure, Stereochemistry, and Biological Activity of Integramycin, a Novel Hexacyclic Natural Product Produced by Actinoplanes sp. that Inhibits HIV-1 Integrase

Singh, Sheo B., Zink, Deborah L., Heimbach, Brian, Genilloud, Olga, Teran, Ana, Silverman, Keith C., Lingham, Russell B., Felock, Peter, Hazuda, Daria J.

Journal:

Organic Letters

Year:

2002

Language:

english

File:

PDF, 75 KB

english, 2002

12

Potential New Therapies for the Treatment of HIV-1 Infection

Condra, Jon H., Miller, Michael D., Hazuda, Daria J., Emini, Emilio A.

Journal:

Annual Review of Medicine

Year:

2002

Language:

english

File:

PDF, 215 KB

english, 2002

13

The Base Excision Repair Pathway Is Required for Efficient Lentivirus Integration

Yoder, Kristine E., Espeseth, Amy, Wang, Xiao-hong, Fang, Qingming, Russo, Maria Teresa, Lloyd, R. Stephen, Hazuda, Daria, Sobol, Robert W., Fishel, Richard, Harris, Reuben

Journal:

Year:

2011

Language:

english

File:

PDF, 1.19 MB

english, 2011

14

P4-187 Development of BACE 1 inhibitors

Brady, Stephen, Bruce, James, Singh, Satendra, Crouthamel, Ming-Chih, Holoway, Katharine M., Coburn, Craig, Vacca, Joseph P., Shafer, Jules A., Hazuda, Daria, Lai, Ming-Tain

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 162 KB

english, 2004

15

Resistance to inhibitors of the human immunodeficiency virus type 1 integration

Hazuda, Daria J.

Journal:

The Brazilian Journal of Infectious Diseases

Year:

2010

Language:

english

File:

PDF, 533 KB

english, 2010

16

The Combination of Grazoprevir, a HCV NS3/4A Protease Inhibitor, and Elbasvir, a HCV NS5A Inhibitor, Demonstrates a High Genetic Barrier to Resistance in HCV Genotype 1a Replicons

Lahser, Frederick C., Bystol, Karin, Curry, Stephanie, McMonagle, Patricia, Xia, Ellen, Ingravallo, Paul, Chase, Robert, Liu, Rong, Black, Todd, Hazuda, Daria, Howe, Anita Y.M., Asante-Appiah, Ernest

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2016

Language:

english

File:

PDF, 1.11 MB

english, 2016

17

ChemInform Abstract: Integrastatins: Structure and HIV-1 Integrase Inhibitory Activities of Two Novel Racemic Tetracyclic Aromatic Heterocycles Produced by Two Fungal Species.

Sheo B. Singh, Deborah L. Zink, Donette S. Quamina, Fernando Pelaez, Ana Teran, Peter Felock, Daria J. Hazuda

Journal:

Year:

2002

File:

PDF, 27 KB

2002

18

Chemical and enzymatic modifications of integric acid and HIV-1 integrase inhibitory activity

Sheo B. Singh, Peter Felock, Daria J. Hazuda

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 171 KB

english, 2000

19

ROUND-UP Service Delivery

Brady, Stephen, Bruce, James, Singh, Satendra, Crouthamel, Ming-Chih, Holoway, Katharine M., Coburn, Craig, Vacca, Joseph P., Shafer, Jules A., Hazuda, Daria, Lai, Ming-Tain

Journal:

Reproductive Health Matters

Year:

2001

Language:

english

File:

PDF, 627 KB

english, 2001

20

Integramides A and B, Two Novel Non-Ribosomal Linear Peptides Containing Nine C α -Methyl Amino Acids Produced by Fungal Fermentations That Are Inhibitors of HIV-1 Integrase

Singh, Sheo B., Herath, Kithsiri, Guan, Ziqiang, Zink, Deborah L., Dombrowski, Anne W., Polishook, Jon D., Silverman, Keith C., Lingham, Russell B., Felock, Peter J., Hazuda, Daria J.

Journal:

Organic Letters

Year:

2002

Language:

english

File:

PDF, 8 KB

english, 2002

21

Host Cell Factors in HIV Replication: Meta-Analysis of Genome-Wide Studies

Bushman, Frederic D., Malani, Nirav, Fernandes, Jason, D'Orso, Iván, Cagney, Gerard, Diamond, Tracy L., Zhou, Honglin, Hazuda, Daria J., Espeseth, Amy S., König, Renate, Bandyopadhyay, Sourav, Ideker,

Journal:

Year:

2009

Language:

english

File:

PDF, 1.19 MB

english, 2009

22

Identification of novel bifunctional HIV-1 reverse transcriptase inhibitors

Lai, Ming-Tain, Tawa, Paul, Auger, Anick, Wang, Deping, Su, Hua-Poo, Yan, Youwei, Hazuda, Daria J., Miller, Michael D., Asante-Appiah, Ernest, Melnyk, Roman A.

Journal:

Journal of Antimicrobial Chemotherapy

Year:

2017

Language:

english

File:

PDF, 646 KB

english, 2017

23

Identification of proximal biomarkers of PKC agonism and evaluation of their role in HIV reactivation

Vemula, Sai Vikram, Maxwell, Jill W., Nefedov, Alexey, Wan, Bang-Lin, Steve, Justin, Newhard, William, Sanchez, Rosa I., Tellers, David, Barnard, Richard J., Blair, Wade, Hazuda, Daria, Webber, Andrea

Journal:

Antiviral Research

Year:

2016

Language:

english

File:

PDF, 1.80 MB

english, 2016

24

Differentiation into an Effector Memory Phenotype Potentiates HIV-1 Latency Reversal in CD4 + T Cells

Kulpa, Deanna A., Talla, Aarthi, Brehm, Jessica H., Ribeiro, Susan Pereira, Yuan, Sally, Bebin-Blackwell, Anne-Gaelle, Miller, Michael, Barnard, Richard, Deeks, Steven G., Hazuda, Daria, Chomont, Nico

Journal:

Journal of Virology

Year:

2019

File:

PDF, 4.14 MB

2019

25

Cellular gene modulation of HIV infected CD4 T cells in response to serial treatment with the histone deacetylase (HDAC) inhibitor vorinostat

Maxwell, Jill W., Falcinelli, Shane D., Nefedov, Alexey, Dorfmeier, Corin, Wu, Guoxin, Dewey, Morgan, Webber, Andrea L., Archin, Nancie M., Margolis, David M., Hazuda, Daria J., Barnard, Richard J.O.,

Journal:

Journal of Virology

Year:

2020

File:

PDF, 2.00 MB

2020

26

Failure of AZT: A molecular perspective

Hazuda, Daria, Kuo, Lawrence

Journal:

Nature Medicine

Year:

1997

File:

PDF, 298 KB

1997

27

The application potential of machine learning and genomics for understanding natural product diversity, chemistry, and therapeutic translatability

Prihoda, David, Maritz, Julia M., Klempir, Ondrej, Dzamba, David, Woelk, Christopher H., Hazuda, Daria J., Bitton, Danny A., Hannigan, Geoffrey D.

Journal:

Natural Product Reports

Year:

2020

File:

PDF, 553 KB

2020

28

Integracides: tetracyclic triterpenoid inhibitors of HIV-1 integrase produced by Fusarium sp.

Sheo B Singh, Deborah L Zink, Anne W Dombrowski, Jon D Polishook, John G Ondeyka, Jorden Hirshfield, Peter Felock, Daria J Hazuda

Journal:

Bioorganic & Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 165 KB

english, 2003

29

Host-Cell Positive Transcription Elongation Factor b Kinase Activity Is Essential and Limiting for HIV Type 1 Replication

Osvaldo Flores, Gary Lee, Joseph Kessler, Michael Miller, William Schlief, Joanne Tomassini and Daria Hazuda

Journal:

Proceedings of the National Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 1.16 MB

english, 1999

30

HIV integrase as a target for antiretroviral therapy

Hazuda, Daria J.

Journal:

Current Opinion in HIV and AIDS

Year:

2012

Language:

english

File:

PDF, 293 KB

english, 2012

31

Discovery and optimization of 2-pyridinone aminal integrase strand transfer inhibitors for the treatment of HIV

Schreier, John D., Embrey, Mark W., Raheem, Izzat T., Barbe, Guillaume, Campeau, Louis-Charles, Dubost, David, McCabe Dunn, Jamie, Grobler, Jay, Hartingh, Timothy J., Hazuda, Daria J., Klein, Daniel,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 2.22 MB

english, 2017

32

ChemInform Abstract: Structure, Stereochemistry, and Biological Activity of Integramycin, a Novel Hexacyclic Natural Product Produced by Actinoplanes sp. that Inhibits HIV-1 Integrase.

Sheo B. Singh, Deborah L. Zink, Brian Heimbach, Olga Genilloud, Ana Teran, Keith C. Silverman, Russell B. Lingham, Peter Felock, Daria J. Hazuda

Journal:

Year:

2002

File:

PDF, 27 KB

2002

33

Radiosynthesis of the HIV integrase inhibitor [18F]MK-0518 (Isentress)

Wenping Li, Wayne Thompson, Thorsten Fisher, John S. Wai, Daria Hazuda, H. Donald Burns, Terence G. Hamill

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

2010

Language:

english

File:

PDF, 168 KB

english, 2010

34

Design and synthesis of substituted 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamides, novel HIV-1 integrase inhibitors

H. Marie Langford, Peter D. Williams, Carl F. Homnick, Joseph P. Vacca, Peter J. Felock, Kara A. Stillmock, Marc V. Witmer, Daria J. Hazuda, Lori J. Gabryelski, William A. Schleif

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 140 KB

english, 2008

35

P2-137 Secretase inhibitors reduce amyloid production in primary neurons from novel MWP HUAPP KI mice

Sethu Sankaranarayanan, Lin Chen, Guoxin Wu, Ming-Chih Crouthamel, Eric A. Price, Richard Z. Chen, Thomas F. Vogt, Shawn Stachel, Craig Coburn, Daria J. Hazuda, Adam J. Simon

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 160 KB

english, 2004

36

Design and Synthesis of 8-Hydroxy-[1,6]Naphthyridines as Novel Inhibitors of HIV-1 Integrase in Vitro and in Infected Cells

Zhuang, Linghang, Wai, John S., Embrey, Mark W., Fisher, Thorsten E., Egbertson, Melissa S., Payne, Linda S., Guare,, James P., Vacca, Joseph P., Hazuda, Daria J., Felock, Peter J., Wolfe, Abigail L.,

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 80 KB

english, 2003

37

Rational Design of Doravirine: From Bench to Patients

Hwang, Carey, Lai, Ming-Tain, Hazuda, Daria J.

Journal:

ACS Infectious Diseases

Year:

2019

Language:

english

File:

PDF, 1.08 MB

english, 2019

38

Innovation and greater probability of success in drug discovery and development — from target to biomarkers

Ismail Kola, Daria Hazuda

Journal:

Current Opinion in Biotechnology

Year:

2005

Language:

english

File:

PDF, 61 KB

english, 2005

39

Resistance to HIV integrase strand transfer inhibitors: in vitro findings and clinical consequences

Grobler, Jay A., Hazuda, Daria J.

Journal:

Current Opinion in Virology

Year:

2014

Language:

english

File:

PDF, 863 KB

english, 2014

40

Structure and absolute stereochemistry of HIV-1 integrase inhibitor integric acid. A novel eremophilane sesquiterpenoid produced by a Xylaria sp.

Sheo B. Singh, Deborah Zink, Jon Polishook, Delia Valentino, Ali Shafiee, Keith Silverman, Peter Felock, Ana Teran, Dolores Vilella, Daria J. Hazuda, Russell B. Lingham

Journal:

Tetrahedron Letters

Year:

1999

Language:

english

File:

PDF, 273 KB

english, 1999

41

A long-acting formulation of the integrase inhibitor raltegravir protects humanized BLT mice from repeated high-dose vaginal HIV challenges

Kovarova, Martina, Swanson, Michael D., Sanchez, Rosa I., Baker, Caroline E., Steve, Justin, Spagnuolo, Rae Ann, Howell, Bonnie J., Hazuda, Daria J., Garcia, J. Victor

Journal:

Journal of Antimicrobial Chemotherapy

Year:

2016

Language:

english

File:

PDF, 467 KB

english, 2016

42

Isolation, Structure and HIV-1 Integrase Inhibitory Activity of Exophillic Acid, a Novel Fungal Metabolite from Exophiala pisciphila

ONDEYKA, JOHN G., ZINK, DEBORAH L., DOMBROWSKI, ANNE W., POLISHOOK, JON D., FELOCK, PETER J., HAZUDA, DARIA J., SINGH, SHEO B.

Journal:

The Journal of Antibiotics

Year:

2003

Language:

english

File:

PDF, 1.11 MB

english, 2003

43

Review of Doravirine Resistance Patterns Identified in Participants During Clinical Development

Martin, Elizabeth Anne, Lai, Ming-Tain, Ngo, Winnie, Feng, Meizhen, Graham, Donald, Hazuda, Daria J., Kumar, Sushma, Hwang, Carey, Sklar, Peter, Asante-Appiah, Ernest

Journal:

JAIDS Journal of Acquired Immune Deficiency Syndromes

Year:

2020

File:

PDF, 135 KB

2020

44

Four Novel Bis-(naphtho-γ-pyrones) Isolated from Fusarium Species as Inhibitors of HIV-1 Integrase.

Sheo B. Singh, Deborah L. Zink, Gerald F. Bills, Ana Teran, Keith C. Silverman, Russell B. Lingham, Peter Felock, Daria J. Hazuda

Journal:

Year:

2003

File:

PDF, 13 KB

2003

45

A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells

Mark W. Embrey, John S. Wai, Timothy W. Funk, Carl F. Homnick, Debbie S. Perlow, Steven D. Young, Joseph P. Vacca, Daria J. Hazuda, Peter J. Felock, Kara A. Stillmock, Marc V. Witmer, Gregory Moyer, W

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 145 KB

english, 2005

46

Inhibitors of human immunodeficiency virus type I

Journal:

Year:

2006

Language:

english

File:

PDF, 68 KB

english, 2006

47

Chemistry and Structure−Activity Relationship of HIV-1 Integrase Inhibitor Integracide B and Related Natural Products

Singh, Sheo B., Ondeyka, John G., Schleif, William A., Felock, Peter, Hazuda, Daria J.

Journal:

Journal of Natural Products

Year:

2003

Language:

english

File:

PDF, 130 KB

english, 2003

48

Isolation, Structure, and HIV-1 Integrase Inhibitory Activity of Cytosporic Acid, a Fungal Metabolite Produced by a Cytospora sp.

Jayasuriya, Hiranthi, Guan, Ziqiang, Polishook, Jon D., Dombrowski, Anne W., Felock, Peter J., Hazuda, Daria J., Singh, Sheo B.

Journal:

Journal of Natural Products

Year:

2003

Language:

english

File:

PDF, 40 KB

english, 2003

49

PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals

Fromentin, Rémi, DaFonseca, Sandrina, Costiniuk, Cecilia T., El-Far, Mohamed, Procopio, Francesco Andrea, Hecht, Frederick M., Hoh, Rebecca, Deeks, Steven G., Hazuda, Daria J., Lewin, Sharon R., Routy

Journal:

Nature Communications

Year:

2019

File:

PDF, 547 KB

2019

50

Isolation, Structure, and HIV-1 Integrase Inhibitory Activity of Xanthoviridicatin E and F, Two Novel Fungal Metabolites Produced by Penicillium chrysogenum

Sheo B. Singh, Deborah L. Zink, Ziqiang Guan, Javier Collado, Fernando Pelaez, Peter J. Felock, Daria J. Hazuda

Journal:

Helvetica Chimica Acta

Year:

2003

Language:

english

File:

PDF, 112 KB

english, 2003

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